This section notes the health information for propolis.
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Authors: Drogovoz SM. Tikhonov AI. Slyshkov VV. Sal'nikova SI.
Title: The liver-protective properties of the pediatric drug form of propolis in animals of different age groups.
Original Title: Izuchenie gepatozashchitnykh svoistv detskoi lekarstvennoi formy propolisa u zhivotnykh raznykh vozrastnykh grupp. (Russian)
Source: Eksperimentalnaia i Klinicheskaia Farmakologiia. 57(4):39-42, 1994 Jul-Aug.

Abstract

The pharmacological activity of a pediatric formulation of the phenolic hydrophobic drug propolis was studied in the experiments on albino rats of various age with toxic liver damages of various duration and in acute hepatic ischemia. In all models of hepatic abnormalities, the drug was found to show antioxidative properties which were moderate (30-60%). In addition, there were improvements in hepatic secretion of bile, cholic acids, and cholesterol. On the other hand, the membrane-stabilizing effect of the drug was exerted in not all the tested models of hepatic damage.

Authors: Amoros M. Lurton E. Boustie J. Girre L. Sauvager F. Cormier M.
Title: Comparison of the anti-herpes simplex virus activities of propolis and 3-methyl-but-2-enyl caffeate.
Source: Journal of Natural Products. 57(5):644-7, 1994 May.

Abstract

The in vitro activity against herpes simplex virus type 1 of 3-methyl-but-2-enyl caffeate isolated from poplar buds or prepared by synthesis was investigated. Under conditions of one or multiple multiplication cycles, this compound, which is a minor constituent of propolis, was found to reduce the viral titer by 3 log10, and viral DNA synthesis by 32-fold.

Authors: Strehl E. Volpert R. Elstner EF.
Title: Biochemical activities of propolis-extracts. III. Inhibition of dihydrofolate reductase.
Source: Zeitschrift fur Naturforschung. Section C. Journal of Biosciences. 49(1-2):39-43, 1994 Jan-Feb.

Abstract

Ethanolic and aqueous extracts of the natural compound PROPOLIS indicate substantial antiinflammatory functions as well as antibiotic activities in vitro and in vivo. The exact mode of physiological or biochemical mechanisms responsible for the medical effects, however, is all but clear. The standardization on the basis of quantitative determination of prominent components of these extracts have been substituted recently by simple biochemical model reactions including photodynamic properties. In this communication we report on the inhibitory activity of an aqueous extract of propolis on the enzyme dihydrofolate reductase. This activity may at least partially be due to the content of caffeic acid, as revealed by HPLC chromatography and comparative activity tests of representative ingredients of the propolis extract. This result may explain some of the protective functions of propolis, similar to those shown for several "non-steroidal antiinflammatory drugs", NSAIDs.

Authors: Focht J. Hansen SH. Nielsen JV. van den Berg-Segers A. Riezler R.
Title: Bactericidal effect of propolis in vitro against agents causing upper respiratory tract infections.
Source: Arzneimittel-Forschung. 43(8):921-3, 1993 Aug.

Abstract

Propolis is a natural product of bees which exhibits an antimicrobial effect. In the study the existence of a bactericidal effect against several strains isolated from patients with infections in their upper respiratory tracts is demonstrated. In light of the use of propolis as a therapeutic agent in natural medicine for common colds and inflammatory processes this effect is discussed.

Authors: Arvouet-Grand A. Lejeune B. Bastide P. Pourrat A. Privat AM. Legret P.
Title: Propolis extract. I. Acute toxicity and determination of acute primary cutaneous irritation index.
Original Title: Extrait de propolis: I. Etude de la toxicite aigue et determination de l'indice d'irritation primaire cutanee. (French)
Source: Journal de Pharmacie de Belgique. 48(3):165-70, 1993 May-Jun.

Abstract

In first part, the aim of this work is to study the orally subacute toxicity of a propolis extract on conscious mice. LD50 is more than 7.34 g/kg propolis extract: this product is not toxic. In second part, cutaneous primary irritation of several products: excipients and propolis extract alone or in ointments, is evaluated in the rabbit. The cutaneous reactions after reiterated applications for 14 days are observed. The index of cutaneous primary irritation is calculated by evaluation of the erythematous and oedematous lesions. The propolis extract is non irritant.

Authors: Krol W. Scheller S. Shani J. Pietsz G. Czuba Z.
Title: Synergistic effect of ethanolic extract of propolis and antibiotics on the growth of staphylococcus aureus.
Source: Arzneimittel-Forschung. 43(5):607-9, 1993 May.

Abstract

Ethanolic extract of propolis (EEP), known to possess marked antibacterial activity, was incubated with 8 different common antibiotics in culture medium containing a fixed amount of a standard strain of Staphylococcus aureus. The antibiotic compounds used were: penicillin G, doxycycline, streptomycin, cloxacillin, chloramphenicol, cefradine, ampicillin and polymyxin B. They were used in varying levels, ranging between 0.000005-125.0 micrograms/ml or units, resp. Firstly, their minimal inhibitory concentrations were established in the absence of EEP, than EEP was added in concentrations up to 600 micrograms/ml. EEP had a marked synergistic effect on the antibacterial activity of streptomycin and cloxacillin, and a moderate synergistic effect on the others, except ampicillin.

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